tag:blogger.com,1999:blog-3434495502175776916.post9106085659316825597..comments2023-04-06T02:43:43.759-07:00Comments on Bitching my way to the Brightside: Hamster RoshamboCrankyOtterhttp://www.blogger.com/profile/02863609824154763580noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-3434495502175776916.post-71734304463642964102012-07-20T15:40:17.190-07:002012-07-20T15:40:17.190-07:00I've been buying large microscope slides for w...I've been buying large microscope slides for work (2"x3" instead of 1"x3") and it's a little freaky because adjacent to these slides in the catalog is the reason they need the wider ones - brain slices. <br /><br />So you can buy what is essentially an egg slicer for various different animal brains, and the wider 2" slides for your rat brain slices. I thought about ordering one but they're $650 or so, which is too much for me to spend on what amounts to an off color joke.<br />http://www.tedpella.com/section_html/asibrain.htm#anchor_ssmatricesCrankyOtterhttps://www.blogger.com/profile/02863609824154763580noreply@blogger.comtag:blogger.com,1999:blog-3434495502175776916.post-12395183482907394252012-06-23T08:40:19.325-07:002012-06-23T08:40:19.325-07:00Two comments based on what I've seen in animal...Two comments based on what I've seen in animal testing:<br /><br />First, one of the newer ways to get more data points from one animal (thus needing fewer animals overall) as well as to have the animal experience fewer separate needle sticks, is to have the animal hooked up to a line that allows for multiple sampling. The animal can roam about its cage while tethered to the line, but I don't think it could run on a wheel without getting tangled.<br /><br />Second, regarding the boredom and measurement-of-stress aspect, most of the mouse studies I've seen data for were of the "dose it for seven days, then euthanize it and puree its liver to look for metabolites" as opposed to long-term dosing and behavioral observation. <br /><br />So yes, if someone is studying fountain-of-youth stuff, then wheels in rodent cages would be a very good thing. For short-term testing of antibiotics or cancer drugs, it's probably not as key, especially if it means not being able to use the continuous sampling approach.Shttp://newdoorknobs.wordpress.com/noreply@blogger.com